Selected article for: "acid change and amino acid change"
Author: Wang, Jingqiang; Ji, Jia; Ye, Jia; Zhao, Xiaoqian; Wen, Jie; Li, Wei; Hu, Jianfei; Li, Dawei; Sun, Min; Zeng, Haipan; Hu, Yongwu; Tian, Xiangjun; Tan, Xuehai; Xu, Ningzhi; Zeng, Changqing; Wang, Jian; Bi, Shengli; Yang, Huanming
Title: The Structure Analysis and Antigenicity Study of the N Protein of SARS-CoV
  • Document date: 2016_11_28
    • ID: s38k8d3l_27
    Snippet: To date there are seventeen isolates of SARS-CoV that have complete sequences. Only four substitutions have been identified in the N protein (Table 5). The substitution rate of the N protein is 0.32%, lower than the average of SARS-CoV genome (0.46%). We suggest that the N protein is much more conserved than other structural proteins for its substitution rate is the lowest among all known proteins. These four substitutions resulted in the change .....
    Document: To date there are seventeen isolates of SARS-CoV that have complete sequences. Only four substitutions have been identified in the N protein (Table 5). The substitution rate of the N protein is 0.32%, lower than the average of SARS-CoV genome (0.46%). We suggest that the N protein is much more conserved than other structural proteins for its substitution rate is the lowest among all known proteins. These four substitutions resulted in the change of three codons. There are two substitutions juxtaposed within the same codon of leucine. One is at the second nucleotide of Codon 140 (nt position 28,519), leading to amino acid change from leucine to tryptophan, and the other is at the third nucleotide of Codon 140 (nt position 28,520) as a synonymous substitution.

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