Author: Hu, Yongwu; Wen, Jie; Tang, Lin; Zhang, Haijun; Zhang, Xiaowei; Li, Yan; Wang, Jing; Han, Yujun; Li, Guoqing; Shi, Jianping; Tian, Xiangjun; Jiang, Feng; Zhao, Xiaoqian; Wang, Jun; Liu, Siqi; Zeng, Changqing; Wang, Jian; Yang, Huanming
Title: The M Protein of SARS-CoV: Basic Structural and Immunological Properties Document date: 2016_11_28
ID: xzlcyn3l_28
Snippet: In an MHV experimental system, the monoclonal antibodies raised against the M protein were able to neutralize infectivity in vitro, thus protecting the host mice against lethal challenge 3., 11.. Two antigenic sites have been detected in the exterior region and could be potentially involved in virus-host interaction supported by our experimental data. An unexpected finding was that all 10 isozymes of the caspase family, which, together with granz.....
Document: In an MHV experimental system, the monoclonal antibodies raised against the M protein were able to neutralize infectivity in vitro, thus protecting the host mice against lethal challenge 3., 11.. Two antigenic sites have been detected in the exterior region and could be potentially involved in virus-host interaction supported by our experimental data. An unexpected finding was that all 10 isozymes of the caspase family, which, together with granzyme and thrombin, are well known to be involved in cell apoptosis, did not have any cleavage sites in the entire M protein. It should be noted that the E protein can induce apoptosis (13), and our data suggest that there may be some protective mechanism in the virus to prevent apoptosis.
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