Author: Liao, Pei-Yu; Choi, Yong Seok; Dinman, Jonathan D.; Lee, Kelvin H.
Title: The many paths to frameshifting: kinetic modelling and analysis of the effects of different elongation steps on programmed –1 ribosomal frameshifting Document date: 2010_9_7
ID: wwq0sd2r_30
Snippet: In Pathway III, À1 PRF occurs during translocation while the pre-translocational complex is aligned with XXY YYZ. The rate constant for the incomplete translocation step is demonstrated by r t3 . Figure 7a shows that a higher r t3 promotes increased FS%. Interestingly, the larger FS% results from an increase in FS z while the level of FS m remains relatively constant (Figure 7a) . Therefore, the fraction of FS m is predicted to decrease as r t3 .....
Document: In Pathway III, À1 PRF occurs during translocation while the pre-translocational complex is aligned with XXY YYZ. The rate constant for the incomplete translocation step is demonstrated by r t3 . Figure 7a shows that a higher r t3 promotes increased FS%. Interestingly, the larger FS% results from an increase in FS z while the level of FS m remains relatively constant (Figure 7a) . Therefore, the fraction of FS m is predicted to decrease as r t3 increases (Figure 7b ). In this case, the majority of FS z is generated from Pathway II when r t3 is <1 s À1 , but the majority of FS z comes from pathway III when r t3 is >1 s À1 (Figure 7b ).
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