Author: Michael Jay Corley; Christopher Sugai; Michael Schotsaert; Robert E. Schwartz; Lishomwa C Ndhlovu
Title: Comparative in vitro transcriptomic analyses of COVID-19 candidate therapy hydroxychloroquine suggest limited immunomodulatory evidence of SARS-CoV-2 host response genes. Document date: 2020_4_14
ID: 30x26ip7_24
Snippet: The copyright holder for this preprint (which was not peer-reviewed) is the . https://doi.org/10.1101/2020.04.13.039263 doi: bioRxiv preprint uninfected individuals. Our comparative analysis of the macrophage HCQ-treated gene set with the COVID-19 lavage transcriptional dataset identified 45 overlapping genes accounting for only 0.84% of differentially expressed genes related to COVID-19 (Fig.4a) . Seven of the 45 genes overlapped with the in vit.....
Document: The copyright holder for this preprint (which was not peer-reviewed) is the . https://doi.org/10.1101/2020.04.13.039263 doi: bioRxiv preprint uninfected individuals. Our comparative analysis of the macrophage HCQ-treated gene set with the COVID-19 lavage transcriptional dataset identified 45 overlapping genes accounting for only 0.84% of differentially expressed genes related to COVID-19 (Fig.4a) . Seven of the 45 genes overlapped with the in vitro SARS-CoV-2 infection transcriptional dataset and included CXCL6, IDI1, MMP1, PLAU, MAFF, BHLHE40, and SLC7A8 genes (Fig.4a-d) . Our data suggest that studies examining the regulation of these genes and relationship to SARS-CoV-2 infection and host immune responses are warranted.
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