Author: Nicholls, John M
Title: The Battle Between Influenza and the Innate Immune Response in the Human Respiratory Tract Document date: 2013_3_29
ID: vyci1ho3_19
Snippet: One of the histological features seen in patients with H5N1 has been the increased numbers of macrophages in the alveolar space [42] . Studies of the ex vivo tissues infected with H5N1 have shown positive antigen in these cells [43] . Unlike the different types of epithelial cells present in the bronchus, alveolar macrophages appear equally susceptible to human and avian influenza virus infection, though H5N1 shows less productive replication in .....
Document: One of the histological features seen in patients with H5N1 has been the increased numbers of macrophages in the alveolar space [42] . Studies of the ex vivo tissues infected with H5N1 have shown positive antigen in these cells [43] . Unlike the different types of epithelial cells present in the bronchus, alveolar macrophages appear equally susceptible to human and avian influenza virus infection, though H5N1 shows less productive replication in alveolar macrophages than bone marrow derived macrophages [44, 45] . Macrophages have receptors for mannose and galactose (MMR and MGL) so this interaction can be Sia independent [46] . As influenza infection appears different in alveolar macrophages compared with bone marrow derived macrophages, extrapolation of studies using the latter to the real clinical picture should be interpreted with caution.
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