Selected article for: "card recruitment domain caspase activation and caspase activation"
Author: Nicholls, John M
Title: The Battle Between Influenza and the Innate Immune Response in the Human Respiratory Tract
  • Document date: 2013_3_29
    • ID: vyci1ho3_37
    Snippet: There are a number of good review articles on this pathway available [59] [60] [61] . These pathways exist in order to distinguish host "self" RNA from invading pathogenic RNA (i.e "non-self"). The intracellular detection of this RNA was ascribed to two cytoplasmic helicases called RIG-I and melanoma differentiationassociated gene 5 product (MDA5). RIG-I has 2 consecutive caspase activation and recruitment domains (CARD), a central helicase domai.....
    Document: There are a number of good review articles on this pathway available [59] [60] [61] . These pathways exist in order to distinguish host "self" RNA from invading pathogenic RNA (i.e "non-self"). The intracellular detection of this RNA was ascribed to two cytoplasmic helicases called RIG-I and melanoma differentiationassociated gene 5 product (MDA5). RIG-I has 2 consecutive caspase activation and recruitment domains (CARD), a central helicase domain and a C-terminal domain (Fig. 3) . Knockout studies showed that RIG-I and MDA5 were able to discriminate between different strains of virus -RIG-I for the ortho, paramyxo and rhabdoviruses and MDA5 for the picornaviruses [62] .

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