Selected article for: "alveolar damage and DAD alveolar damage"
Author: Nicholls, John M
Title: The Battle Between Influenza and the Innate Immune Response in the Human Respiratory Tract
  • Document date: 2013_3_29
    • ID: vyci1ho3_4
    Snippet: The emergence of H5N1 in isolated cases and the 2009 pandemic demonstrated a crucial factor in the understanding of influenza pathogenesis. In fatal case in the 2009 pandemic large numbers of influenza antigen positive cells were present in the lungs of fatal cases [8] . In contrast, patients who died of H5N1 rarely had abundant numbers of antigen positive cells -even though changes of diffuse alveolar damage (DAD) were present [9] [10] [11] . Si.....
    Document: The emergence of H5N1 in isolated cases and the 2009 pandemic demonstrated a crucial factor in the understanding of influenza pathogenesis. In fatal case in the 2009 pandemic large numbers of influenza antigen positive cells were present in the lungs of fatal cases [8] . In contrast, patients who died of H5N1 rarely had abundant numbers of antigen positive cells -even though changes of diffuse alveolar damage (DAD) were present [9] [10] [11] . Since this latter group of patients died after antiviral and intensive care therapy [12] [13] [14] , the picture was similar to that seen in SARS, where there was an acute viral induced disease with antigen present followed by a second phase of DAD where antigen was not identified but an evolving process of alveolar destruction followed by repair had commenced [15] .

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