Author: Perlman, Stanley
Title: The Middle East Respiratory Syndrome—How Worried Should We Be? Document date: 2013_8_20
ID: r52vu3p8_10
Snippet: Interspersed between and within these four structural proteins are five accessory proteins that are unique to MERS-CoV. Accessory proteins are encoded by all coronaviruses, are not essential for virus replication, may be structural or nonstructural, and can be deleted without affecting pathogenesis (for examples, see references 7 and 8). A few are apparently involved in facilitating virus assembly or in immunoevasion, but the functions of the oth.....
Document: Interspersed between and within these four structural proteins are five accessory proteins that are unique to MERS-CoV. Accessory proteins are encoded by all coronaviruses, are not essential for virus replication, may be structural or nonstructural, and can be deleted without affecting pathogenesis (for examples, see references 7 and 8). A few are apparently involved in facilitating virus assembly or in immunoevasion, but the functions of the others are not known (9) . MERS-CoV accessory proteins share no homology with any known host or virus protein, other than those of the closely related BtCoV-HKU4 and -HKU5 strains of bat coronavirus (4).
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