Author: Hao, Xin-yan; Lv, Qi; Li, Feng-di; Xu, Yan-feng; Gao, Hong
Title: The characteristics of hDPP4 transgenic mice subjected to aerosol MERS coronavirus infection via an animal nose-only exposure device Document date: 2019_10_30
ID: vkjcheaz_53
Snippet: F I G U R E 5 Immunohistochemical staining of mouse tissue samples after infection. A, Immunohistochemical staining of the lungs of infected mice. B, Immunohistochemical staining of the brains of infected mice. C, Immunohistochemical staining of the kidneys of infected mice. Mice in the instillation group died acutely or were euthanized when they researched 25% weight loss; these mice had a 0% survival rate by day 5, so no tissue lesion results w.....
Document: F I G U R E 5 Immunohistochemical staining of mouse tissue samples after infection. A, Immunohistochemical staining of the lungs of infected mice. B, Immunohistochemical staining of the brains of infected mice. C, Immunohistochemical staining of the kidneys of infected mice. Mice in the instillation group died acutely or were euthanized when they researched 25% weight loss; these mice had a 0% survival rate by day 5, so no tissue lesion results were available on days 7 and 9 7-9 days. After intranasal infection, however, the levels of IL-1β, IL-6, IL-10, TNF-α, and IFN-γ in the lungs and IL-6, IL-8, IL-10, and IFN-γ in the brains peaked at 3-5 days. The secretion of some cytokines and chemokines in the aerosol group was slower than that in the intranasal group (P < .05).
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