Author: Li, Dongbo; Ji, Hongfei; Niu, Xingjian; Yin, Lei; Wang, Yiran; Gu, Yucui; Wang, Jinlu; Zhou, Xiaoping; Zhang, Han; Zhang, Qingyuan
Title: Tumor-associated macrophages secrete CC-chemokine ligand 2 and induce tamoxifen resistance by activating PI3K/Akt/mTOR in breast cancer Document date: 2019_12_19
ID: yj9mb88g_3
Snippet: The molecular mechanism underlying endocrine resistance of breast cancer is highly complicated and involves many molecules and pathways such as overexpression of epidermal growth factor receptor and/or the HER-2/neu/ErbB2 oncogene, 31 mutations in ER or loss of ER-alpha expression, 32,33 activation of the MAPK 32 and PI3K/Akt/mTOR signaling pathways, 34 and overexpression of cytochrome P450 (CYP450) enzymes. 35 Among these factors, the activation.....
Document: The molecular mechanism underlying endocrine resistance of breast cancer is highly complicated and involves many molecules and pathways such as overexpression of epidermal growth factor receptor and/or the HER-2/neu/ErbB2 oncogene, 31 mutations in ER or loss of ER-alpha expression, 32,33 activation of the MAPK 32 and PI3K/Akt/mTOR signaling pathways, 34 and overexpression of cytochrome P450 (CYP450) enzymes. 35 Among these factors, the activation of the PI3K/Akt/mTOR signaling pathway is dominant.
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