Author: Perlman, Stanley
Title: The Middle East Respiratory Syndrome—How Worried Should We Be? Document date: 2013_8_20
ID: r52vu3p8_13
Snippet: Events occurring immediately after MERS-CoV binds its DPP4 Perspective receptor appear to be similar to those reported for other coronaviruses. Cleavage of the surface glycoprotein must occur to expose the fusion peptide and to effect virus-cell membrane fusion and nucleocapsid release into the cytoplasm. Several host proteases, including cathepsin B and members of the TMPRSS family, have been implicated in this process (15) ......
Document: Events occurring immediately after MERS-CoV binds its DPP4 Perspective receptor appear to be similar to those reported for other coronaviruses. Cleavage of the surface glycoprotein must occur to expose the fusion peptide and to effect virus-cell membrane fusion and nucleocapsid release into the cytoplasm. Several host proteases, including cathepsin B and members of the TMPRSS family, have been implicated in this process (15) .
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