Author: Salaun, Christine; Greaves, Jennifer; Chamberlain, Luke H.
Title: The intracellular dynamic of protein palmitoylation Document date: 2010_12_27
ID: svn4e6w6_20
Snippet: Classically, palmitoylation dynamics have been studied using radiolabeled palmitate and pulse-chase protocols; for example, proteins or could instead reflect a different rate of palmitate turnover and subsequent Golgi recycling (Fig. 2) . Interestingly, proteins in this category, including Fyn, TC10, R-Ras, RhoB, and Rap2C all displayed colocalization with a Golgi marker when vesicular traffic through the secretory pathway was blocked by low temp.....
Document: Classically, palmitoylation dynamics have been studied using radiolabeled palmitate and pulse-chase protocols; for example, proteins or could instead reflect a different rate of palmitate turnover and subsequent Golgi recycling (Fig. 2) . Interestingly, proteins in this category, including Fyn, TC10, R-Ras, RhoB, and Rap2C all displayed colocalization with a Golgi marker when vesicular traffic through the secretory pathway was blocked by low temperature . This observation implies that after their synthesis, these proteins traffic via the Golgi and is consistent with the notion that the Golgi may be a specialized reaction center for the palmitoylation of all newly synthesized peripheral proteins and for a subset that undergo rapid depalmitoylation dynamics.
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