Author: Xie, Xin-Hui; Wang, Xin-Luan; Yang, Hui-Lin; Zhao, De-Wei; Qin, Ling
Title: Steroid-associated osteonecrosis: Epidemiology, pathophysiology, animal model, prevention, and potential treatments (an overview) Document date: 2015_1_13
ID: y6y235hw_24
Snippet: As well as bone matrix degradation, SAON was also characterised by the diffuse presence of empty lacunae or pyknotic nuclei of osteocytes in bone trabeculae [12,24e26] . If the death of the bone subsequently induces an inadequate repair process, the bone underlying the joint surface will be weakened. The steroid not only decreases the function of osteoblasts and osteoclasts, but also induces the apoptosis of osteoblasts and osteocytes. The steroi.....
Document: As well as bone matrix degradation, SAON was also characterised by the diffuse presence of empty lacunae or pyknotic nuclei of osteocytes in bone trabeculae [12,24e26] . If the death of the bone subsequently induces an inadequate repair process, the bone underlying the joint surface will be weakened. The steroid not only decreases the function of osteoblasts and osteoclasts, but also induces the apoptosis of osteoblasts and osteocytes. The steroid-treated mice exhibited a threefold increase in osteoblast apoptosis in vertebrae and showed apoptosis in 28% of the osteocytes in metaphyseal cortical bone. Clinical research showed that nitric oxide metabolism was altered in bone cells during the development of ON at the femoral head and was accompanied by widespread apoptosis of osteoblasts and osteocytes, which suggested that the nitric oxide-mediated apoptosis was a potential mechanism for SAON [27] .
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