Author: Zhou, Ya-Qun; Liu, Dai-Qiang; Chen, Shu-Ping; Sun, Jia; Zhou, Xue-Rong; Xing, Cui; Ye, Da-Wei; Tian, Yu-Ke
Title: The Role of CXCR3 in Neurological Diseases Document date: 2019_2_23
ID: xago1ts3_5
Snippet: To conclude, the clinical studies provided compelling evidence that CXCR3 is involved in the development of MS and its antagonists may become novel agents for the management of MS. However, further study with larger sample size and longer follow-up are warranted to investigate the feasibility of CXCR3 antagonists and its exact mechanism in alleviating MS. The animal studies also proposed a protective role of CXCR3 in EAE and may provide novel ins.....
Document: To conclude, the clinical studies provided compelling evidence that CXCR3 is involved in the development of MS and its antagonists may become novel agents for the management of MS. However, further study with larger sample size and longer follow-up are warranted to investigate the feasibility of CXCR3 antagonists and its exact mechanism in alleviating MS. The animal studies also proposed a protective role of CXCR3 in EAE and may provide novel insights into intervention strategies. However, the underlying mechanisms of how CXCR3 exerts its protective role in EAE need further investigations.
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