Author: Teoh, Kim-Tat; Siu, Yu-Lam; Chan, Wing-Lim; Schlüter, Marc A.; Liu, Chia-Jen; Peiris, J. S. Malik; Bruzzone, Roberto; Margolis, Benjamin; Nal, Béatrice
Title: The SARS Coronavirus E Protein Interacts with PALS1 and Alters Tight Junction Formation and Epithelial Morphogenesis Document date: 2010_11_15
ID: ufw13pjx_49
Snippet: We then investigated whether another TJ protein, the ZO-1 protein, could also be relocalized to the virus assembly site in SARS-CoV infected cells (Figure 3B, panel c). Interestingly, PALS1 was present in an intracellular compartment, whereas ZO-1 was exclusively found at cell-cell contact zones. This result indicates that PALS1 is specifically recruited to the virus budding compartment (ERGIC/Golgi region) in infected cells......
Document: We then investigated whether another TJ protein, the ZO-1 protein, could also be relocalized to the virus assembly site in SARS-CoV infected cells (Figure 3B, panel c). Interestingly, PALS1 was present in an intracellular compartment, whereas ZO-1 was exclusively found at cell-cell contact zones. This result indicates that PALS1 is specifically recruited to the virus budding compartment (ERGIC/Golgi region) in infected cells.
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