Selected article for: "immune evasion and viral replication"
Author: Roshan Kumar; Helianthous Verma; Nirjara Singhvi; Utkarsh Sood; Vipin Gupta; Mona Singh; Rashmi Sharma; Princy Hira; Shekhar Nagar; Chandni Talwar; Namita Nayyar; Shailly Anand; Charu Dogra Rawat; Mansi Verma; Ram Kishan Negi; Yogendra Singh; Rup Lal
Title: Comparative Genomic Analysis of Rapidly Evolving SARS CoV-2 Viruses Reveal Mosaic Pattern of Phylogeographical Distribution
  • Document date: 2020_3_30
    • ID: eqwxkwqa_35
    Snippet: The copyright holder for this preprint (which was not peer-reviewed) is the . https://doi.org/10.1101/2020.03.25.006213 doi: bioRxiv preprint infection and pathogenesis of SARS-CoV-2 is still not clear and under investigation. To 283 explore the role of SARS-CoV-2 proteins in host immune evasion, the SARSCoV-2 proteins 284 were mapped over host proteome database ( Figure 3B & Table 3 ). We identified a total of 28 285 proteins from host proteome .....
    Document: The copyright holder for this preprint (which was not peer-reviewed) is the . https://doi.org/10.1101/2020.03.25.006213 doi: bioRxiv preprint infection and pathogenesis of SARS-CoV-2 is still not clear and under investigation. To 283 explore the role of SARS-CoV-2 proteins in host immune evasion, the SARSCoV-2 proteins 284 were mapped over host proteome database ( Figure 3B & Table 3 ). We identified a total of 28 285 proteins from host proteome forming close association with 25 viral proteins present in 9 ORFs 286 of SARS-CoV-2 ( Figure 3C ). The network was trimmed in Cytoscape v3.7.2 where only 287 interacting proteins were selected. Only 12 viral proteins were found to interact with host 288 proteins ( Figure 3A ). Detailed analysis of interactome highlighted 9 host proteins in direct 289 association with 6 viral proteins. Further, the network was analyzed for identification of 290 regulatory hubs based on degree analysis. We identified mitogen activated protein kinase 1 291 Similarly, the viral protein Papain-like proteinase (PL-PRO) which has deubiquitinase and 309 deISGylating activity is responsible for cleaving viral polyprotein into 3 mature proteins which 310 are essential for viral replication [57] . Our study showed that PL-PRO directly interacts with 311 PPP1CA which is a protein phosphatase that associates with over 200 regulatory host proteins 312 to form highly specific holoenzymes. PL-PRO is also found to interact with TGFβ which is a 313 beta transforming growth factor and promotes T-helper 17 cells (Th17) and regulatory T-cells 314 (Treg) differentiation [58] . Reports have shown the PL-PRO induced upregulation of TGFβ in 315 author/funder. All rights reserved. No reuse allowed without permission.

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