Selected article for: "disease severity and severity relate"
Author: Kim, Chang-Keun; Callaway, Zak; Gern, James E.
Title: Viral Infections and Associated Factors That Promote Acute Exacerbations of Asthma
  • Document date: 2017_10_13
    • ID: u4rtnyj7_13
    Snippet: Host factors may be critical in determining RSV-induced disease severity, even when taking age-related effects, current/recent infection, air pollution, and allergen exposure into account. 44 Host genetic studies have found several polymorphisms to relate to RSV severity, including those in the chemokine receptor CCR5 50 (which binds a number of inflammatory CC-chemokines, including MIP-1α, MIP-1β, and RANTES), CXCL8, IL-4, and promoter variant.....
    Document: Host factors may be critical in determining RSV-induced disease severity, even when taking age-related effects, current/recent infection, air pollution, and allergen exposure into account. 44 Host genetic studies have found several polymorphisms to relate to RSV severity, including those in the chemokine receptor CCR5 50 (which binds a number of inflammatory CC-chemokines, including MIP-1α, MIP-1β, and RANTES), CXCL8, IL-4, and promoter variants of IL-9, IL-10, and TNF-α. 51 Thus, gene-environment interactions may contribute to susceptibility to virus-induced disease.

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