Author: te Velthuis, Aartjan J.W.; van den Worm, Sjoerd H. E.; Snijder, Eric J.
Title: The SARS-coronavirus nsp7+nsp8 complex is a unique multimeric RNA polymerase capable of both de novo initiation and primer extension Document date: 2011_10_29
ID: tx0lqgff_44
Snippet: The complex replication and transcription process that coronaviruses initiate upon infection involves up to 16 viral nsps and at least one host factor (30) (31) (32) . Both individually as well as in complex with each other, these subunits engage in numerous protein-protein interactions (17, 33) and embody various enzymatic activities, including proteolytic (19, 34) , ATPase (35) , and 5 0 cap modifying reactions (36) . Remarkably though, the mec.....
Document: The complex replication and transcription process that coronaviruses initiate upon infection involves up to 16 viral nsps and at least one host factor (30) (31) (32) . Both individually as well as in complex with each other, these subunits engage in numerous protein-protein interactions (17, 33) and embody various enzymatic activities, including proteolytic (19, 34) , ATPase (35) , and 5 0 cap modifying reactions (36) . Remarkably though, the mechanism and enzymes required to catalyse RNA synthesis in the CoV RTC remain very poorly understood. Moreover, uniquely among RNA viruses which generally employ a single RNA polymerase to drive their RNA synthesis (1, 2) , the polymerase activity assays and nsp8 mutagenesis documented in this and other studies suggest that, in addition to the presumed nsp12 'main RdRp', other polymerase activities could play a critical role in the synthesis of SARS-CoV RNAs (10, 12, 37, 38) .
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