Selected article for: "ACE homologue and acute lung failure"
Author: Wu, Huajie; Li, Yan; Wang, Yanxia; Xu, Dunquan; Li, Congcong; Liu, Manling; Sun, Xin; Li, Zhichao
Title: Tanshinone IIA Attenuates Bleomycin-Induced Pulmonary Fibrosis via Modulating Angiotensin-Converting Enzyme 2/ Angiotensin-(1-7) Axis in Rats
  • Document date: 2014_4_7
    • ID: td2uk2wc_2
    Snippet: Recent studies showed that renin angiotensin system (RAS) is involved in the progression of PF evidenced by angiotensinogen (AGT) genes polymorphism association with PF, and its overexpression in those patients with PF [4, 5] . After cleaved by angiotensin converting enzyme (ACE), angiotensin (ANG) I turns into ANG II. The activated ANG II answers for up-regulating transforming growth factor-β (TGF-β) which is pivotal in modulating the differen.....
    Document: Recent studies showed that renin angiotensin system (RAS) is involved in the progression of PF evidenced by angiotensinogen (AGT) genes polymorphism association with PF, and its overexpression in those patients with PF [4, 5] . After cleaved by angiotensin converting enzyme (ACE), angiotensin (ANG) I turns into ANG II. The activated ANG II answers for up-regulating transforming growth factor-β (TGF-β) which is pivotal in modulating the differentiation of fibroblast to myofibroblasts [6] . Moreover, ANG II is also believed to associate with inflammatory responses and cell apoptosis during the progress of various lung diseases [7, 8] . Recent discovery of a homologue of ACE, named ACE-2, and its enzymatic product ANG-(1-7) could counter the detrimental effects of ACE and offer beneficial effects by limiting ANGII accumulation during kinds of pathophysiological processes [9] [10] [11] . Studies also demonstrated that ACE-2/ANGA (1-7) plays a key negative regulatory factor for severity of lung edema and acute lung failure [12, 13] . Recently, the protective effects of ACE-2/ANG-(1-7) during the progression of PF were increasingly being investigated [14] [15] [16] .

    Search related documents:
    Co phrase search for related documents
    • ACE enzyme and ANG II turn: 1
    • ACE enzyme and angiotensin ACE enzyme convert: 1, 2
    • ACE enzyme and angiotensin system: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
    • ACE enzyme and beneficial effect: 1, 2, 3
    • ACE enzyme and cell apoptosis: 1, 2, 3, 4
    • ACE enzyme convert and angiotensin ACE enzyme convert: 1, 2
    • ACE homologue and acute lung failure: 1, 2, 3
    • ACE homologue and acute lung failure lung edema severity: 1
    • ACE homologue and angiotensin system: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23
    • acute lung failure and angiotensin system: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10
    • acute lung failure and cell apoptosis: 1
    • AGT gene and angiotensin system: 1
    • ANG II turn and angiotensin system: 1, 2
    • angiotensin system and beneficial effect: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11
    • angiotensin system and cell apoptosis: 1, 2, 3, 4, 5, 6, 7, 8
    • beneficial effect and cell apoptosis: 1