Author: Vandergriff, Adam; Huang, Ke; Shen, Deliang; Hu, Shiqi; Hensley, Michael Taylor; Caranasos, Thomas G.; Qian, Li; Cheng, Ke
Title: Targeting regenerative exosomes to myocardial infarction using cardiac homing peptide Document date: 2018_2_14
ID: yi8zv3co_37
Snippet: Our results demonstrate an effective method for increasing the potency of CDC-XOs for cardiac regeneration through the use of Cardiac Homing Peptide. The use of DOPE-NHS allows for peptides or other molecules to be conjugated to exosomes and possibly other membrane-based nanoparticles. Targeting the exosomes resulted in increased uptake in cardiomyocytes in vitro, as well as increased functional recovery in an animal model by reducing fibrosis, i.....
Document: Our results demonstrate an effective method for increasing the potency of CDC-XOs for cardiac regeneration through the use of Cardiac Homing Peptide. The use of DOPE-NHS allows for peptides or other molecules to be conjugated to exosomes and possibly other membrane-based nanoparticles. Targeting the exosomes resulted in increased uptake in cardiomyocytes in vitro, as well as increased functional recovery in an animal model by reducing fibrosis, inducing cardiomyocyte proliferation and increasing angiogenesis. The use of cardiac-targeted exosomes represents a promising method for the treatment of myocardial infarction.
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