Author: Gendron, Karine; Ferbeyre, Gerardo; Heveker, Nikolaus; Brakier-Gingras, Léa
Title: The activity of the HIV-1 IRES is stimulated by oxidative stress and controlled by a negative regulatory element Document date: 2010_10_8
ID: qtn3ukf4_27
Snippet: M12 was shown by Abbink et al. (55) to favor the BMH conformation whereas M16 favored the LDI conformation. Both mutants had a similar effect on the IRES activity, which does not support an involvement of the proposed BMH-LDI switch in the IRES activity. Abbink et al. had already observed that such a switch did not influence translation of the HIV-1 full-length mRNA, using conditions where cap-dependent translation predominates. Our results indic.....
Document: M12 was shown by Abbink et al. (55) to favor the BMH conformation whereas M16 favored the LDI conformation. Both mutants had a similar effect on the IRES activity, which does not support an involvement of the proposed BMH-LDI switch in the IRES activity. Abbink et al. had already observed that such a switch did not influence translation of the HIV-1 full-length mRNA, using conditions where cap-dependent translation predominates. Our results indicate that this putative switch has also no impact on the IRES activity but they reveal two additional regions that can influence HIV-1 IRES activity.
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