Title: The single transmembrane segment of gp210 is sufficient for sorting to the pore membrane domain of the nuclear envelope Document date: 1992_12_2
ID: vznqgnzd_4
Snippet: How is gp210 sorted to the pore membrane after its signaland stop-~ansfer sequence-mediated integration into the RER and the outer nuclear membrane? Like resident integral proteins of the RER and the NE, gp210 is designed to resist bulk flow from the RER into downstream membranes of the exocytotic pathway. In addition, it is sorted specifically to the pore membrane of the NE. Retention in the ER of a number of resident integral proteins, both end.....
Document: How is gp210 sorted to the pore membrane after its signaland stop-~ansfer sequence-mediated integration into the RER and the outer nuclear membrane? Like resident integral proteins of the RER and the NE, gp210 is designed to resist bulk flow from the RER into downstream membranes of the exocytotic pathway. In addition, it is sorted specifically to the pore membrane of the NE. Retention in the ER of a number of resident integral proteins, both endogenous and viral, has been shown to be mediated by sequences in the cytoplasmically exposed domains of these proteins (13, 24, 26) . Because of its likely interaction with the NPC, the cytoplasmically exposed tail of gp210 seemed a likely candidate to be the determinant for sorting to the pore membrane. However, using various mutant forms of gp210, we found that its TM is sufficient for sorting to the pore membrane. The cytoplasmic tail (CT) serves as an additional, but weaker, sorting determinant.
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