Selected article for: "egfp PALS1 and MDCKII egfp PALS1"
Author: Teoh, Kim-Tat; Siu, Yu-Lam; Chan, Wing-Lim; Schlüter, Marc A.; Liu, Chia-Jen; Peiris, J. S. Malik; Bruzzone, Roberto; Margolis, Benjamin; Nal, Béatrice
Title: The SARS Coronavirus E Protein Interacts with PALS1 and Alters Tight Junction Formation and Epithelial Morphogenesis
  • Document date: 2010_11_15
    • ID: ufw13pjx_65
    Snippet: Expression of HA-E (ΔPBM) also led to a severe phenotype with only 24% (208/863) of the MDCKII eGFP-PALS1, HA-E (ΔPBM) cysts displaying a single lumen (p < 0.001, unpaired t test) (Figure 5B and C). The defect of cyst morphogenesis observed in MDCKII cells expressing HA-E (ΔPBM) mutant protein suggests that the DLLV motif is not involved in this phenomenon and that other domains in E may interact with other cellular pathways implicated in morp.....
    Document: Expression of HA-E (ΔPBM) also led to a severe phenotype with only 24% (208/863) of the MDCKII eGFP-PALS1, HA-E (ΔPBM) cysts displaying a single lumen (p < 0.001, unpaired t test) (Figure 5B and C). The defect of cyst morphogenesis observed in MDCKII cells expressing HA-E (ΔPBM) mutant protein suggests that the DLLV motif is not involved in this phenomenon and that other domains in E may interact with other cellular pathways implicated in morphogenesis of cysts.

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