Author: Méndez-Sánchez, Nahum; Valencia-Rodríguez, Alejandro; Qi, Xingshun; Yoshida, Eric M.; Romero-Gómez, Manuel; George, Jacob; Eslam, Mohammed; Abenavoli, Ludovico; Xie, Weifen; Teschke, Rolf; Carrion, Andres F.; Keaveny, Andrew P.
Title: What Has the COVID-19 Pandemic Taught Us so Far? Addressing the Problem from a Hepatologist’s Perspective Document date: 2020_4_11
ID: tiixwaqi_8
Snippet: A recent mouse model of acute liver injury with partial hepatectomy found that at day 1 post-hepatectomy, hepatic expression of ACE2 in rats was downregulated. From day 3, there was an up to two-fold increased expression of this receptor, with a normalization of values on day 7, when the liver recovered and hepatocyte proliferation ceased. 17 With this information, the authors proposed that the systemic inflammation derived from significant NCP c.....
Document: A recent mouse model of acute liver injury with partial hepatectomy found that at day 1 post-hepatectomy, hepatic expression of ACE2 in rats was downregulated. From day 3, there was an up to two-fold increased expression of this receptor, with a normalization of values on day 7, when the liver recovered and hepatocyte proliferation ceased. 17 With this information, the authors proposed that the systemic inflammation derived from significant NCP could trigger liver necrosis and hepatocyte proliferation, upregulating the expression of ACE2 and therefore worsening liver injury. Similarly, liver biopsies from SARS-CoV patients showed a significant increase in mitotic cell numbers, with eosinophilic bodies and balloon-like hepatocytes, 18 supporting a role for SARS-CoV-2 in the development of liver injury.
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