Selected article for: "case study and study design"
Author: Thornton, Hannah V; Hay, Alastair D; Redmond, Niamh M; Turnbull, Sophie L; Christensen, Hannah; Peters, Tim J; Leeming, John P; Lovering, Andrew; Vipond, Barry; Muir, Peter; Blair, Peter S
Title: Throat swabs in children with respiratory tract infection: associations with clinical presentation and potential targets for point-of-care testing
  • Document date: 2017_2_18
    • ID: r3fzwy00_48
    Snippet: Previous work seeking associations between microbe detection and clinical presentation has mostly been conducted in secondary care (hospital settings). A previous systematic review searched primary and secondary care literature for the association of microbe detection with symptoms and signs in children and found a broad absence of evidence in this area (10) . Regarding the follow-up study, Rhedin et al. published a case-control study in 2014 whi.....
    Document: Previous work seeking associations between microbe detection and clinical presentation has mostly been conducted in secondary care (hospital settings). A previous systematic review searched primary and secondary care literature for the association of microbe detection with symptoms and signs in children and found a broad absence of evidence in this area (10) . Regarding the follow-up study, Rhedin et al. published a case-control study in 2014 which compared viral detection rates in nasopharyngeal aspirates from 225 children attending emergency departments in Sweden with and without symptoms of RTI (16) . Despite differences in study design, population and country, of note is the agreement of the follow-up study findings of a small/no relative decrease between the prevalence of enterovirus and coronavirus in children with and without RTI. Marked decreases in rhinovirus and RSV prevalence were also replicated. Additionally, decreases in rhinovirus and RSV detection were observed by Regamey et al. in a 2008 study of nasal swabs from 128 children during and after RTI (17) . However, this study also reported a pronounced fall in coronavirus detection, in contrast to our follow-up study results, perhaps reflecting differences in coronavirus strains circulating in this population.

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