Author: Wang, Jingqiang; Ji, Jia; Ye, Jia; Zhao, Xiaoqian; Wen, Jie; Li, Wei; Hu, Jianfei; Li, Dawei; Sun, Min; Zeng, Haipan; Hu, Yongwu; Tian, Xiangjun; Tan, Xuehai; Xu, Ningzhi; Zeng, Changqing; Wang, Jian; Bi, Shengli; Yang, Huanming
Title: The Structure Analysis and Antigenicity Study of the N Protein of SARS-CoV Document date: 2016_11_28
ID: s38k8d3l_21
Snippet: Previous experiments showed that hydrophobic residues, such as cysteine, leucine and valine, on the surface of the protein are most likely to be part of antigenic determinants. Based on a semi-empirical method through making a statistics of appearance frequency of each amino acid in known segmental epitopes (11), we have predicted 16 antigenic sites of the N protein and found they are clustering in the middle and the C-terminus (Figure 4 and Tabl.....
Document: Previous experiments showed that hydrophobic residues, such as cysteine, leucine and valine, on the surface of the protein are most likely to be part of antigenic determinants. Based on a semi-empirical method through making a statistics of appearance frequency of each amino acid in known segmental epitopes (11), we have predicted 16 antigenic sites of the N protein and found they are clustering in the middle and the C-terminus (Figure 4 and Table 3). There is a strong antigenic site (TALALLLLDR) located around Codons 218-227. In addition, another three strong antigenic sites were detected around Codons 156-166 (AATVLQLPQGT), Codons 347-363 (FKDNVILLNKHIDAYKT) and Codons 389-398 (KQPTVTLLPA) (Table 3).
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