Author: Chan, Jasper Fuk-Woo; Zhang, Anna Jinxia; Chan, Chris Chung-Sing; Yip, Cyril Chik-Yan; Mak, Winger Wing-Nga; Zhu, Houshun; Poon, Vincent Kwok-Man; Tee, Kah-Meng; Zhu, Zheng; Cai, Jian-Piao; Tsang, Jessica Oi-Ling; Chik, Kenn Ka-Heng; Yin, Feifei; Chan, Kwok-Hung; Kok, Kin-Hang; Jin, Dong-Yan; Au-Yeung, Rex Kwok-Him; Yuen, Kwok-Yung
Title: Zika Virus Infection in Dexamethasone-immunosuppressed Mice Demonstrating Disseminated Infection with Multi-organ Involvement Including Orchitis Effectively Treated by Recombinant Type I Interferons Document date: 2016_11_12
ID: v4r5d26a_4
Snippet: Because of these limitations and knowledge gaps, we developed and characterized a more readily available mouse model which resembles immunosuppressed hosts with disseminated infection. We showed that these mice developed inflammation in multiple organs, including the testes, which may have important implications on ZIKV's longterm outcome and effects on fertility. We also utilized this novel animal model to show that early treatment with clinical.....
Document: Because of these limitations and knowledge gaps, we developed and characterized a more readily available mouse model which resembles immunosuppressed hosts with disseminated infection. We showed that these mice developed inflammation in multiple organs, including the testes, which may have important implications on ZIKV's longterm outcome and effects on fertility. We also utilized this novel animal model to show that early treatment with clinically approved recombinant type I interferons improved the clinical outcome of these mice.
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