Author: Cereda, Maurizio; Xin, Yi; Hamedani, Hooman; Bellani, Giacomo; Kadlecek, Stephen; Clapp, Justin; Guerra, Luca; Meeder, Natalie; Rajaei, Jennia; Tustison, Nicholas J; Gee, James C; Kavanagh, Brian P; Rizi, Rahim R
Title: Tidal changes on CT and progression of ARDS Document date: 2017_6_20
ID: sncded7z_4
Snippet: We first characterised the analysis of paired EI-EE CT scans in laboratory experiments (anaesthetised rats). We then used serial CT scans in rats and confirmed that areas of lung with the greatest differences in paired EI-EE aeration at baseline (potentially representing atelectrauma and local strain) corresponded to the areas of maximum progression of injury. Finally, we used paired EI-EE CT images from a small group (n=9) of patients with ARDS .....
Document: We first characterised the analysis of paired EI-EE CT scans in laboratory experiments (anaesthetised rats). We then used serial CT scans in rats and confirmed that areas of lung with the greatest differences in paired EI-EE aeration at baseline (potentially representing atelectrauma and local strain) corresponded to the areas of maximum progression of injury. Finally, we used paired EI-EE CT images from a small group (n=9) of patients with ARDS â–º Personalised management and selective recruitment to clinical trials is challenging in acute respiratory distress syndrome (ARDS) because conventional parameters do not predict individual responses or outcome; thus, patients are often managed with a simplified and uniform approach.
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