Selected article for: "activation response and host benefit"

Author: Raison, C L; Miller, A H
Title: The evolutionary significance of depression in Pathogen Host Defense (PATHOS-D)
  • Document date: 2012_1_31
  • ID: twgs7akl_13_1
    Snippet: of cell types. For example, macrophages rely on L-type calcium channel activation in response to Chlamydia pneumonia lipopolysaccharide to kill the microorganism. 160 However, other microbes have evolved to manipulate this host defense system to their own benefit, such as Legionella pneumophila, which requires L-type calcium signaling to replicate within infected host cells. 161 These examples demonstrate that the same physiological process can e.....
    Document: of cell types. For example, macrophages rely on L-type calcium channel activation in response to Chlamydia pneumonia lipopolysaccharide to kill the microorganism. 160 However, other microbes have evolved to manipulate this host defense system to their own benefit, such as Legionella pneumophila, which requires L-type calcium signaling to replicate within infected host cells. 161 These examples demonstrate that the same physiological process can enhance host defense to one pathogen, while simultaneously increasing vulnerability to another.

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