Author: Jasenosky, Luke D.; Cadena, Cristhian; Mire, Chad E.; Borisevich, Viktoriya; Haridas, Viraga; Ranjbar, Shahin; Nambu, Aya; Bavari, Sina; Soloveva, Veronica; Sadukhan, Supriya; Cassell, Gail H.; Geisbert, Thomas W.; Hur, Sun; Goldfeld, Anne E.
Title: The FDA-Approved Oral Drug Nitazoxanide Amplifies Host Antiviral Responses and Inhibits Ebola Virus Document date: 2019_8_8
ID: yomg30hg_4
Snippet: With no effective and easily deployable oral drug to treat or prevent infection, EBOV caused over 10,000 deaths in the 2014-2016 west African EBOV epidemic (Shiwani et al., 2017) and has claimed over 1,700 lives to date (as of July 21, 2019) in the current outbreak in the Democratic Republic of the Congo (Claude et al., 2018; World Health Organization, 2019) . Our demonstration that NTZ significantly inhibits EBOV replication in vitro suggests th.....
Document: With no effective and easily deployable oral drug to treat or prevent infection, EBOV caused over 10,000 deaths in the 2014-2016 west African EBOV epidemic (Shiwani et al., 2017) and has claimed over 1,700 lives to date (as of July 21, 2019) in the current outbreak in the Democratic Republic of the Congo (Claude et al., 2018; World Health Organization, 2019) . Our demonstration that NTZ significantly inhibits EBOV replication in vitro suggests that NTZ could have a potential role in the treatment of acute EBOV disease, prevention of EBOV infection in exposed healthy individuals, and eradication of EBOV reservoirs that persist in immune-privileged sites of patients who have been cured of EBOV disease (Deen et al., 2017) , and it provides impetus to test NTZ in animal models of EBOV infection to demonstrate in vivo efficacy.
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