Author: Josset, Laurence; Zeng, Hui; Kelly, Sara M.; Tumpey, Terrence M.; Katze, Michael G.
Title: Transcriptomic Characterization of the Novel Avian-Origin Influenza A (H7N9) Virus: Specific Host Response and Responses Intermediate between Avian (H5N1 and H7N7) and Human (H3N2) Viruses and Implications for Treatment Options Document date: 2014_2_4
ID: uz0m1o0q_2
Snippet: There is great concern over potential further adaptation of H7N9 to humans and acquisition of sustainable person-to-person transmissibility. In addition, a recent study pointed out that H7N9 acquired resistance to neuraminidase (NA) inhibitors in 2 out of 14 hospitalized patients that had been treated with oseltamivir or peramivir (18) . Emergence of H7N9 virus resistant to neuraminidase inhibitors is concerning, since this virus is also naturall.....
Document: There is great concern over potential further adaptation of H7N9 to humans and acquisition of sustainable person-to-person transmissibility. In addition, a recent study pointed out that H7N9 acquired resistance to neuraminidase (NA) inhibitors in 2 out of 14 hospitalized patients that had been treated with oseltamivir or peramivir (18) . Emergence of H7N9 virus resistant to neuraminidase inhibitors is concerning, since this virus is also naturally resistant to M2 ion channel blockers and no vaccine is yet available.
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