Selected article for: "antigen presentation and host response"
Author: Josset, Laurence; Zeng, Hui; Kelly, Sara M.; Tumpey, Terrence M.; Katze, Michael G.
Title: Transcriptomic Characterization of the Novel Avian-Origin Influenza A (H7N9) Virus: Specific Host Response and Responses Intermediate between Avian (H5N1 and H7N7) and Human (H3N2) Viruses and Implications for Treatment Options
  • Document date: 2014_2_4
    • ID: uz0m1o0q_3
    Snippet: In this study, we applied global transcriptomic profiling to human cells infected with H7N9 Anhui01 or with other avian or human IAV to broadly characterize the host response to infection and quickly identify FDA-approved drugs that may act as antivirals. We show that H7N9 induces both a specific response and responses intermediate between those to H3N2 and those to avian H5N1 and H7N7. Notably, H7N9 induced a downregulation of the antigen presen.....
    Document: In this study, we applied global transcriptomic profiling to human cells infected with H7N9 Anhui01 or with other avian or human IAV to broadly characterize the host response to infection and quickly identify FDA-approved drugs that may act as antivirals. We show that H7N9 induces both a specific response and responses intermediate between those to H3N2 and those to avian H5N1 and H7N7. Notably, H7N9 induced a downregulation of the antigen presentation pathway and delayed proinflammatory cytokine induction to a greater extent than H5N1 and H7N7, which could have an important impact on in vivo immune responses. Similar to H3N2, H7N9 induced minor changes in eicosanoid signaling and genes implicated in chromatin modification. Finally, we computationally predicted that several FDA-approved drugs were able to reverse the host response to H7N9 and may be antivirals against this emerging virus. One of these drugs, minocycline, exhibited anti-H7N9 activity in vitro.

    Search related documents:
    Co phrase search for related documents
    • antigen presentation pathway downregulation and host response: 1
    • antiviral act and host response: 1, 2, 3, 4, 5, 6, 7
    • antiviral act and human cell: 1
    • antiviral act and immune response: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10
    • chromatin modification and cytokine induction: 1
    • chromatin modification and eicosanoid signaling: 1, 2
    • chromatin modification and host response: 1, 2
    • chromatin modification and human cell: 1, 2
    • cytokine induction and eicosanoid signaling: 1
    • cytokine induction and host response: 1, 2, 3, 4, 5, 6
    • cytokine induction and human cell: 1, 2, 3, 4, 5, 6, 7, 8
    • eicosanoid signaling and host response: 1
    • eicosanoid signaling and human cell: 1
    • emerge virus and human cell: 1, 2