VIGOR extended to annotate genomes for additional 12 different viruses

Wang, Shiliang; Sundaram, Jaideep P.; Stockwell, Timothy B.

A total of 101 complete genomes of measles and mump viruses were downloaded from NCBI. VIGOR predicted 774 genes, whereas GenBank record indicates 759 genes in these genomes. VIGOR detected 15 new genes validated by comparing them with other viral proteins (data not shown here). Most of them are the C protein gene, which overlaps with P protein gene but in a different reading frame. Five VIGOR predictions have different start codons with the same reading frame as GenBank annotations. All these five predictions are the fusion protein gene. Like the M2-1 protein of MPV, two versions of fusion protein exist in the GenBank protein database. VIGOR selected the longer one as the reference sequence to define the start codon. In GenBank annotations, the downstream ATG was selected as the start codon.