Selected article for: "mcmv infection and NK cell"
Author: Madera, Sharline; Rapp, Moritz; Firth, Matthew A.; Beilke, Joshua N.; Lanier, Lewis L.; Sun, Joseph C.
Title: Type I IFN promotes NK cell expansion during viral infection by protecting NK cells against fratricide
  • Document date: 2016_2_8
    • ID: qkdni38b_6
    Snippet: Given the rescue of the maturation defect of Ifnar −/− NK cells in mixed bone marrow chimeric mice (Mizutani et al., 2012) , we assessed the ability of Ly49H + Ifnar −/− and Stat1 −/− NK cells from mixed chimeras to undergo clonal expansion in response to MCMV infection. After adoptive transfer and infection, Ifnar −/− NK cells were unable to expand as robustly as their WT counterparts (Fig. 3 D) . Similarly, mixed chimera-derived.....
    Document: Given the rescue of the maturation defect of Ifnar −/− NK cells in mixed bone marrow chimeric mice (Mizutani et al., 2012) , we assessed the ability of Ly49H + Ifnar −/− and Stat1 −/− NK cells from mixed chimeras to undergo clonal expansion in response to MCMV infection. After adoptive transfer and infection, Ifnar −/− NK cells were unable to expand as robustly as their WT counterparts (Fig. 3 D) . Similarly, mixed chimera-derived Stat1 −/− NK cells also exhibited a marked defect in expansion after MCMV infection compared with WT NK cells (Fig. 3 E) . Long-lived NK cells were also diminished in NK cell populations that lack IFN AR or STAT1 (Fig. 3 , D and E), highlighting the critical role of type I IFN signaling in NK cells for a robust viral-specific response.

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