Author: Ishibashi, Daisuke; Homma, Takujiro; Nakagaki, Takehiro; Fuse, Takayuki; Sano, Kazunori; Satoh, Katsuya; Mori, Tsuyoshi; Atarashi, Ryuichiro; Nishida, Noriyuki
Title: Type I interferon protects neurons from prions in in vivo models Document date: 2019_2_7
ID: zopwlaq4_50
Snippet: Using quantitative high-throughput screening, RO8191 was identified as a novel small molecule that acts like I-IFNs by directly interacting with the I-IFN receptor to drive interferon-stimulated gene expression. RO8191 can positively bind to the IFNAR2 receptor and strongly evoke an IFN signal inducing interferon-stimulated gene expression (Konishi et al., 2012) . Thus, RO8191 can markedly block hepatitis C virus replication and cell death after .....
Document: Using quantitative high-throughput screening, RO8191 was identified as a novel small molecule that acts like I-IFNs by directly interacting with the I-IFN receptor to drive interferon-stimulated gene expression. RO8191 can positively bind to the IFNAR2 receptor and strongly evoke an IFN signal inducing interferon-stimulated gene expression (Konishi et al., 2012) . Thus, RO8191 can markedly block hepatitis C virus replication and cell death after encephalomyocarditis virus infection in cell culture as demonstrated with recombinant IFN treatment (Konishi et al., 2012; Wang et al., 2015) . Moreover, mice orally inoculated with RO8191 showed significantly higher expression of Animals were intracerebrally or intraperitoneally administrated with 10 À1 to 10 À3 dilution of brain homogenate from 22 L prion-infected terminal mice. *P 5 0.05, **P 5 0.01, ***P 5 0.001.
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