Author: Ishibashi, Daisuke; Homma, Takujiro; Nakagaki, Takehiro; Fuse, Takayuki; Sano, Kazunori; Satoh, Katsuya; Mori, Tsuyoshi; Atarashi, Ryuichiro; Nishida, Noriyuki
Title: Type I interferon protects neurons from prions in in vivo models Document date: 2019_2_7
ID: zopwlaq4_50
Snippet: Using quantitative high-throughput screening, RO8191 was identified as a novel small molecule that acts like I-IFNs by directly interacting with the I-IFN receptor to drive interferon-stimulated gene expression. RO8191 can positively bind to the IFNAR2 receptor and strongly evoke an IFN signal inducing interferon-stimulated gene expression (Konishi et al., 2012) . Thus, RO8191 can markedly block hepatitis C virus replication and cell death after .....
Document: Using quantitative high-throughput screening, RO8191 was identified as a novel small molecule that acts like I-IFNs by directly interacting with the I-IFN receptor to drive interferon-stimulated gene expression. RO8191 can positively bind to the IFNAR2 receptor and strongly evoke an IFN signal inducing interferon-stimulated gene expression (Konishi et al., 2012) . Thus, RO8191 can markedly block hepatitis C virus replication and cell death after encephalomyocarditis virus infection in cell culture as demonstrated with recombinant IFN treatment (Konishi et al., 2012; Wang et al., 2015) . Moreover, mice orally inoculated with RO8191 showed significantly higher expression of Animals were intracerebrally or intraperitoneally administrated with 10 À1 to 10 À3 dilution of brain homogenate from 22 L prion-infected terminal mice. *P 5 0.05, **P 5 0.01, ***P 5 0.001.
Search related documents:
Co phrase search for related documents- cell culture and quantitative high throughput screening: 1
- cell culture and recombinant IFN treatment: 1
- cell culture and small molecule: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
- cell culture and virus infection: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
- cell culture virus infection and virus infection: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18
- cell death and small molecule: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21
- cell death and virus infection: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
- directly interact and small molecule: 1
- directly interact and terminal mouse: 1
- directly interact and virus infection: 1, 2, 3, 4, 5
- gene expression and recombinant IFN treatment: 1
- gene expression and significantly high expression: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12
- gene expression and small molecule: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
- gene expression and virus infection: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
- high throughput and quantitative high throughput screening: 1, 2, 3, 4, 5, 6
- high throughput and significantly high expression: 1
- high throughput and small molecule: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
- high throughput and virus infection: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
- high throughput screening and quantitative high throughput screening: 1, 2, 3, 4, 5, 6
Co phrase search for related documents, hyperlinks ordered by date