Author: Li, Li; Wang, Li; Xiao, Ruijing; Zhu, Guoguo; Li, Yan; Liu, Changxuan; Yang, Ru; Tang, Zhiqing; Li, Jie; Huang, Wei; Chen, Lang; Zheng, Xiaoling; He, Yuling; Tan, Jinquan
Title: The invasion of tobacco mosaic virus RNA induces endoplasmic reticulum stress-related autophagy in HeLa cells Document date: 2011_11_21
ID: r4c1sngt_64_1
Snippet: of viral passage in HeLa cells. When the replication of TMV-RNA in HeLa cells is further verified, a mouse tumour model could be established by administering TMV-RNA-treated HeLa cells or untreated HeLa cells in vivo and assessing whether TMV-RNA can also induce autophagy and replication in vivo. Although autophagy is primarily a protective process for the cell, it can also play a role in cell death. Thus, if TMV-RNA-induced autophagy occurs in v.....
Document: of viral passage in HeLa cells. When the replication of TMV-RNA in HeLa cells is further verified, a mouse tumour model could be established by administering TMV-RNA-treated HeLa cells or untreated HeLa cells in vivo and assessing whether TMV-RNA can also induce autophagy and replication in vivo. Although autophagy is primarily a protective process for the cell, it can also play a role in cell death. Thus, if TMV-RNA-induced autophagy occurs in vivo, it would cause rapid tumour cell death, further inhibiting the growth of the tumour. If this scenario proves true, TMV-RNA may be used as a therapy for human tumours in the future.
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