Author: Sneha Rath; Eliza Prangley; Jesse Donovan; Kaitlin Demarest; Yigal Meir; Ned Wingreen; Alexei Korennykh
Title: Concerted 2-5A-Mediated mRNA Decay and Transcription Reprogram Protein Synthesis in dsRNA Response Document date: 2018_12_4
ID: ng5c7xai_71
Snippet: The main observation is that while basal mRNAs decay, the rate of increase of IFNs is only slightly reduced in the presence of RNase L (Fig. S7A ). The simplest model to describe the dynamics of IFN mRNAs is that, in the absence of RNase L, they increase exponentially due to direct positive feedback according to the rate equation:.....
Document: The main observation is that while basal mRNAs decay, the rate of increase of IFNs is only slightly reduced in the presence of RNase L (Fig. S7A ). The simplest model to describe the dynamics of IFN mRNAs is that, in the absence of RNase L, they increase exponentially due to direct positive feedback according to the rate equation:
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