Author: Li, Dongbo; Ji, Hongfei; Niu, Xingjian; Yin, Lei; Wang, Yiran; Gu, Yucui; Wang, Jinlu; Zhou, Xiaoping; Zhang, Han; Zhang, Qingyuan
Title: Tumor-associated macrophages secrete CC-chemokine ligand 2 and induce tamoxifen resistance by activating PI3K/Akt/mTOR in breast cancer Document date: 2019_12_19
ID: yj9mb88g_21
Snippet: The protocol for this study was approved by the Ethics Committee of positivity. CCL2 immunoreactivity was scored by staining intensity (negative, weak, moderate, or strong staining) and the percentage of positive tumor cells per core (≤25%, >25%-50%, >50%-75%, and >75%). Tissues were considered positive for CCL2 expression with ≥moderate staining intensity in >25% of the cells examined. Yellow granules indicated CD163 positivity. CD163 immuno.....
Document: The protocol for this study was approved by the Ethics Committee of positivity. CCL2 immunoreactivity was scored by staining intensity (negative, weak, moderate, or strong staining) and the percentage of positive tumor cells per core (≤25%, >25%-50%, >50%-75%, and >75%). Tissues were considered positive for CCL2 expression with ≥moderate staining intensity in >25% of the cells examined. Yellow granules indicated CD163 positivity. CD163 immunoreactivity was scored as the infiltration density of CD163+ macrophages ranging from 0 (absent) to 3 (dense). A score equal to or greater than 1 was regarded as positive.
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