Author: Perlman, Stanley
Title: The Middle East Respiratory Syndrome—How Worried Should We Be? Document date: 2013_8_20
ID: r52vu3p8_9
Snippet: MERS-CoV is a large, positive-sense, single-stranded virus containing 30,119 nucleotides (4). The genome encodes both nonstructural and structural proteins. Replicase-associated nonstructural proteins comprise two-thirds of the genome and are translated into a large polyprotein that is then cleaved into 16 proteins. These proteins are conserved in all coronaviruses, and partly as a consequence of the intense research efforts addressed at understa.....
Document: MERS-CoV is a large, positive-sense, single-stranded virus containing 30,119 nucleotides (4). The genome encodes both nonstructural and structural proteins. Replicase-associated nonstructural proteins comprise two-thirds of the genome and are translated into a large polyprotein that is then cleaved into 16 proteins. These proteins are conserved in all coronaviruses, and partly as a consequence of the intense research efforts addressed at understanding SAR-CoV, the structure and function of many of these proteins are known. The structural proteins encoded at the 3= end of the genome are the same as those found in other coronaviruses and include a nucleocapsid protein, a spike glycoprotein essential for cell entry, and two membrane proteins involved in virus assembly and structure.
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