Author: Madera, Sharline; Rapp, Moritz; Firth, Matthew A.; Beilke, Joshua N.; Lanier, Lewis L.; Sun, Joseph C.
Title: Type I IFN promotes NK cell expansion during viral infection by protecting NK cells against fratricide Document date: 2016_2_8
ID: qkdni38b_3
Snippet: Type I IFNs signal through STAT1-STAT2 heterodimers and STAT1-STAT1 homodimers (Li et al., 1996) . Therefore, we determined the role of STAT1 in the NK cell response to MCMV infection using STAT1-deficient mice. Equal numbers of WT and Stat1 −/− Ly49H + NK cells were cotransferred into Ly49H-deficient hosts and then infected with MCMV. Similar to Ifnar −/− NK cells, Stat1 −/− NK cells exhibited a striking defect in expansion during th.....
Document: Type I IFNs signal through STAT1-STAT2 heterodimers and STAT1-STAT1 homodimers (Li et al., 1996) . Therefore, we determined the role of STAT1 in the NK cell response to MCMV infection using STAT1-deficient mice. Equal numbers of WT and Stat1 −/− Ly49H + NK cells were cotransferred into Ly49H-deficient hosts and then infected with MCMV. Similar to Ifnar −/− NK cells, Stat1 −/− NK cells exhibited a striking defect in expansion during the immune response to MCMV infection ( Fig. 2 A) , even though Stat1 −/− NK cells were able to mature nearly as well as WT NK cells after infection (Fig. 2, B and C) . These data support the importance of STAT1-mediated type I IFN signaling in NK cells for an optimal antiviral NK cell response.
Search related documents:
Co phrase search for related documents- cell response and ifn signal: 1
- cell response and immune response: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
- cell response and mcmv infection: 1, 2, 3, 4, 5
- cell response and mouse mcmv infection: 1
- cell response and NK cell: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
- cell response and NK cell response: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
- cell response and NK cell signal: 1
- equal number and immune response: 1
- ifn signal and immune response: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12
- ifn signal and NK cell: 1, 2, 3
- immune response and mcmv infection: 1, 2, 3, 4
- immune response and mouse mcmv infection: 1
- immune response and NK cell: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
- immune response and NK cell response: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13
- immune response and NK cell signal: 1
- mcmv infection and mouse mcmv infection: 1, 2, 3, 4, 5, 6
- mcmv infection and nearly mature: 1
- mcmv infection and NK cell: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
- mcmv infection and NK cell response: 1, 2, 3
Co phrase search for related documents, hyperlinks ordered by date