Author: Ishibashi, Daisuke; Homma, Takujiro; Nakagaki, Takehiro; Fuse, Takayuki; Sano, Kazunori; Satoh, Katsuya; Mori, Tsuyoshi; Atarashi, Ryuichiro; Nishida, Noriyuki
Title: Type I interferon protects neurons from prions in in vivo models Document date: 2019_2_7
ID: zopwlaq4_51
Snippet: several interferon-stimulated genes compared with the vehicle group (Konishi et al., 2012) . RO8191 inhibited PrP Sc in prion-infected cells but did not change the PrP C level (Fig. 5) . Prion-infected mice that were intraperitoneally treated with RO8191 showed significantly prolonged survival periods and were resistant to pathological changes in the brain after prion infection (Fig. 6) . Several low molecular weight compounds (NPRs), which provi.....
Document: several interferon-stimulated genes compared with the vehicle group (Konishi et al., 2012) . RO8191 inhibited PrP Sc in prion-infected cells but did not change the PrP C level (Fig. 5) . Prion-infected mice that were intraperitoneally treated with RO8191 showed significantly prolonged survival periods and were resistant to pathological changes in the brain after prion infection (Fig. 6) . Several low molecular weight compounds (NPRs), which provide stabilization were detected by immunoblotting. Statistical significance was determined using one-way ANOVA, followed by Dunnett's test in multiple comparisons. **P 5 0.01 and ***P 5 0.001. Results in the graph present the mean AE SEM from at least three to five independent experiments.
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