Author: Wang, Shiliang; Sundaram, Jaideep P.; Stockwell, Timothy B.
Title: VIGOR extended to annotate genomes for additional 12 different viruses Document date: 2012_6_4
ID: wd3ir3wg_14
Snippet: Within the P gene region of parainfluenza viruses and Sendai virus, a maximum of four proteins (C', C, Y1 and Y2) are encoded in addition to the P, V and D proteins by a mechanism known as ribosomal shunting (also known as alternative translation initiation) (10). The start codon of C protein gene is downstream the start codon of P protein gene, but the reading frame of C protein gene is different. VIGOR predicts the C protein coding sequence fir.....
Document: Within the P gene region of parainfluenza viruses and Sendai virus, a maximum of four proteins (C', C, Y1 and Y2) are encoded in addition to the P, V and D proteins by a mechanism known as ribosomal shunting (also known as alternative translation initiation) (10). The start codon of C protein gene is downstream the start codon of P protein gene, but the reading frame of C protein gene is different. VIGOR predicts the C protein coding sequence first. The next two in-frame ATG codons in the C protein coding sequence will be the start codons of the Y1 and Y2 protein genes (11) . The start codon (ACG or GCG) of C' protein will be scanned upstream of the P protein start codon (7 to 15 nt) (12) , but in the same reading frame as the C protein gene.
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