Author: Yamashita, Masamichi
Title: Aspirin Intolerance: Experimental Models for Bed-to-Bench Document date: 2016_12_23
ID: ry6xr4ix_30
Snippet: We previously observed that auranofin, a gold compound for rheumatoid arthritis, induced a COX-1-dependent increase of PGE 2 production without significant induction of COX-1 protein within 4 h after inflammatory treatment of rat peritoneal macrophages, while nitric oxide production was not increased [25, 26, 31] . It was also reported that auranofin induces p23, a co-chaperone of heat shock protein 90 that was later identified as cPGES (Fig. 2) .....
Document: We previously observed that auranofin, a gold compound for rheumatoid arthritis, induced a COX-1-dependent increase of PGE 2 production without significant induction of COX-1 protein within 4 h after inflammatory treatment of rat peritoneal macrophages, while nitric oxide production was not increased [25, 26, 31] . It was also reported that auranofin induces p23, a co-chaperone of heat shock protein 90 that was later identified as cPGES (Fig. 2) [70] . If reduction of PG synthesis via cPGES/COX-1 plays an important role in AERD, auranofin or other cPGES activator(s) could be effective for this condition.
Search related documents:
Co phrase search for related documents- heat shock and important role: 1, 2, 3, 4, 5, 6, 7
- heat shock and inflammatory treatment: 1
- heat shock and nitric oxide production: 1
- heat shock and oxide production: 1
- heat shock and rheumatoid arthritis: 1
- heat shock and significant induction: 1
- heat shock protein and important role: 1, 2, 3, 4
- heat shock protein and nitric oxide production: 1
- heat shock protein and oxide production: 1
- heat shock protein and significant induction: 1
- important role and inflammatory treatment: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22
- important role and nitric oxide production: 1, 2, 3, 4, 5, 6, 7
- important role and oxide production: 1, 2, 3, 4, 5, 6, 7
- important role and peritoneal macrophage: 1
- important role and rheumatoid arthritis: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18
- important role and significant induction: 1, 2
- inflammatory treatment and nitric oxide production: 1, 2
- inflammatory treatment and oxide production: 1, 2, 3
- inflammatory treatment and rheumatoid arthritis: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34
Co phrase search for related documents, hyperlinks ordered by date