Author: Yamashita, Masamichi
Title: Aspirin Intolerance: Experimental Models for Bed-to-Bench Document date: 2016_12_23
ID: ry6xr4ix_36
Snippet: Aspirin and other NSAIDs are also reported to affect various mitochondrial enzyme complexes, including NADHubiquinone oxidoreductase (complex I), succinate dehydrogenase (complex II), cytochrome bc 1 complex (complex III) and cytochrome c oxidase (complex IV) [72, 73] . Antimycin, a specific complex III inhibitor, is reported to inhibit histamine release from experimentally stimulated human mast cells obtained by bronchoalveolar lavage [74] . Ant.....
Document: Aspirin and other NSAIDs are also reported to affect various mitochondrial enzyme complexes, including NADHubiquinone oxidoreductase (complex I), succinate dehydrogenase (complex II), cytochrome bc 1 complex (complex III) and cytochrome c oxidase (complex IV) [72, 73] . Antimycin, a specific complex III inhibitor, is reported to inhibit histamine release from experimentally stimulated human mast cells obtained by bronchoalveolar lavage [74] . Antimycin was also reported to increase reactive oxygen species in the mitochondria of a pollen extract-treated A549 human alveolar epithelial cell line and the authors suggested that damage to mitochondrial respiration-related proteins may exacerbate inflammation [75] .
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