Author: Dawson, Patrick; Malik, Mamunur Rahman; Parvez, Faruque; Morse, Stephen S.
Title: What Have We Learned About Middle East Respiratory Syndrome Coronavirus Emergence in Humans? A Systematic Literature Review Document date: 2019_3_1
ID: yb54i1ne_42
Snippet: Macrophages also appear to play an important role, but there are limited and somewhat ambiguous data from the mouse model , human cells , and patients (Faure et al. 2014) . With a number of viruses, it is not unusual for resting macrophages to be permissive for replication but for macrophages to show antiviral activity after activation (such as by IFN-c) (Morse and Morahan 1981) . Dendritic cells have been reported to produce IFN in response to i.....
Document: Macrophages also appear to play an important role, but there are limited and somewhat ambiguous data from the mouse model , human cells , and patients (Faure et al. 2014) . With a number of viruses, it is not unusual for resting macrophages to be permissive for replication but for macrophages to show antiviral activity after activation (such as by IFN-c) (Morse and Morahan 1981) . Dendritic cells have been reported to produce IFN in response to infection (Scheuplein et al. 2015) .
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