Selected article for: "effective treatment and MERS CoV"
Author: Dawson, Patrick; Malik, Mamunur Rahman; Parvez, Faruque; Morse, Stephen S.
Title: What Have We Learned About Middle East Respiratory Syndrome Coronavirus Emergence in Humans? A Systematic Literature Review
  • Document date: 2019_3_1
    • ID: yb54i1ne_51
    Snippet: Although neutralizing antibodies induced during infection did not appear to be protective during natural infection (Corman et al. 2016 , Zhao et al. 2017 , human convalescent sera containing neutralizing antibodies conferred dosedependent protection in a mouse model (Zhao et al. 2017 ). The readily available sera from MERS-immune camels apparently were also an effective treatment for MERS-infected mice and reduced the severity of pathological cha.....
    Document: Although neutralizing antibodies induced during infection did not appear to be protective during natural infection (Corman et al. 2016 , Zhao et al. 2017 , human convalescent sera containing neutralizing antibodies conferred dosedependent protection in a mouse model (Zhao et al. 2017 ). The readily available sera from MERS-immune camels apparently were also an effective treatment for MERS-infected mice and reduced the severity of pathological changes in murine lung tissue . Several monoclonal antibodies (mAbs) , Ohnuma et al. 2013 , Jiang et al. 2014 , Tang et al. 2014 , Ying et al. 2014 , Houser et al. 2016 ) and conventional antibodies (Zhao et al. 2013 ) have demonstrated effective neutralization of MERS-CoV, and could serve as potential therapeutic agents, at least in the interim.

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