Author: Christensen, Maria H; Paludan, Søren R
Title: Viral evasion of DNA-stimulated innate immune responses Document date: 2016_3_14
ID: pvdlox4j_1
Snippet: Mammalian cells express pattern recognition receptors (PRR) and are therefore able to detect microbes. The PRRs are activated upon binding to conserved molecular structures, called pathogen-associated molecular patterns (PAMPs), to induce expression of antiviral and proinflammatory proteins. 1,2 The fact that most PAMPs are expressed only by microbes and not by host cells, allows the innate immune system to respond specifically to non-self. In ad.....
Document: Mammalian cells express pattern recognition receptors (PRR) and are therefore able to detect microbes. The PRRs are activated upon binding to conserved molecular structures, called pathogen-associated molecular patterns (PAMPs), to induce expression of antiviral and proinflammatory proteins. 1,2 The fact that most PAMPs are expressed only by microbes and not by host cells, allows the innate immune system to respond specifically to non-self. In addition to pathogen-specific PAMPs, DNA is a potent stimulator of antimicrobial responses. 1, 3 To discriminate between DNA derived from the microbes versus the host, DNA sensors are present in the cytosol, as well as in endosomal membrane structures, that is, compartments expected to be free of host DNA.
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