Author: Evans, Claire F.; Horwitz, Marc S.; Hobbs, Monte V.; Oldstone, Michael B.A.
Title: Viral Infection of Transgenic Mice Expressing a Viral Protein in Oligodendrocytes Leads to Chronic Central Nervous System Autoimmune Disease Document date: 1996_12_1
ID: t82a9y5s_17
Snippet: Effects of LCMV Infection of Transgenic Mice. Transgenic positive and negative mice from the two MBP-NP and two MBP-GP lines ( Fig. 1 C ) , bred to the F2-F4 level, were infected peripherally with LCMV. After i.p. infection of immunocompetent mice with LCMV, viral replication occurs in many tissues and cell types, but not within the CNS (14, 30) . This was confirmed by in situ hybridization studies using LCMV-specific riboprobes after i.p. infect.....
Document: Effects of LCMV Infection of Transgenic Mice. Transgenic positive and negative mice from the two MBP-NP and two MBP-GP lines ( Fig. 1 C ) , bred to the F2-F4 level, were infected peripherally with LCMV. After i.p. infection of immunocompetent mice with LCMV, viral replication occurs in many tissues and cell types, but not within the CNS (14, 30) . This was confirmed by in situ hybridization studies using LCMV-specific riboprobes after i.p. infection of transgenic mice (data not shown). Clearance of LCMV in BALB/c and C57BL/6 mice normally occurs within 7-14 d after infection and is mediated by a vigorous CD8 Ï© CTL response (13, 14, 31) . When assessed by plaque assays of serum samples, transgenic positive mice cleared virus with the same kinetics as transgenic negative mice.
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