Selected article for: "amino acid and cell host"
Author: Roshan Kumar; Helianthous Verma; Nirjara Singhvi; Utkarsh Sood; Vipin Gupta; Mona Singh; Rashmi Sharma; Princy Hira; Shekhar Nagar; Chandni Talwar; Namita Nayyar; Shailly Anand; Charu Dogra Rawat; Mansi Verma; Ram Kishan Negi; Yogendra Singh; Rup Lal
Title: Comparative Genomic Analysis of Rapidly Evolving SARS CoV-2 Viruses Reveal Mosaic Pattern of Phylogeographical Distribution
  • Document date: 2020_3_30
    • ID: eqwxkwqa_43
    Snippet: SNPs and showed amino acid substitutions in ORF1b protein and S-protein, while one of them 368 also harbored an amino-acid addition. This is suggestive of the severity of the mutating viral 369 genomes within the population of the USA. These proteins are directly involved in the 370 formation of viral replication-transcription complexes (RTC). Therefore, we argue that the 371 novel SARS-CoV-2 has fast evolving replicative machinery and that it is.....
    Document: SNPs and showed amino acid substitutions in ORF1b protein and S-protein, while one of them 368 also harbored an amino-acid addition. This is suggestive of the severity of the mutating viral 369 genomes within the population of the USA. These proteins are directly involved in the 370 formation of viral replication-transcription complexes (RTC). Therefore, we argue that the 371 novel SARS-CoV-2 has fast evolving replicative machinery and that it is urgent to consider 372 these mutants to develop strategies for COVID-19 treatment. The ORF1ab polyprotein protein 373 and S-protein were also found to have dN/dS values approaching 1 and thus might confer a 374 selective advantage to evade host responsive mechanisms. The construction of SARS-CoV-2-375 human interactome revealed that its pathogenicity is mediated by a surge in pro-inflammatory 376 cytokine. It is predicted that major immune-pathogenicity mechanism by SARS-CoV-2 377 includes the host cell environment alteration by disintegration by signal transduction pathways 378 and immunity evasion by several protection mechanisms. The mode of entry of this virus by 379 S-proteins inside the host cell is still unclear but it might be similar to SARS CoV-1 like 380 author/funder. All rights reserved. No reuse allowed without permission.

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